Biological Physics
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Research Topics
Publications
2022
- Wilharm N, Fischer T, Hayn A, Mayr SG
Structural Breakdown of Collagen Type I Elastin Blend Polymerization
Polymers 14(20), 4434 (2022)
DOI:10.3390/polym14204434 - Mierke CT, Hayn A, Fischer T
PINCH1 Promotes Fibroblast Migration in Extracellular Matrices and Influences Their Mechanophenotype
Frontiers in Cell and Developmental Biology 10:869563 (2022)
DOI:10.3389/fcell.2022.869563
2021
- Aermes C, Hayn A, Fischer T, Mierke CT
Cell mechanical properties of human breast carcinoma cells depend on temperature
Scientific Reports 11:10771 (2021)
DOI:10.1038/s41598-021-90173-y
2020
- Hayn A, Fischer T, Mierke CT
Inhomogeneities in 3D collagen matrices impact matrix mechanics and cancer cell migration
Frontiers in Cell and Developmental Biology (2020)
DOI:10.3389/fcell.2020.593879 - Mierke CT, Puder S, Aermes C, Fischer T, Kunschmann T
Effect of PAK Inhibition on Cell Mechanics Depends on Rac1
Frontiers in Cell and Developmental Biology 8:13 (2020)
DOI:10.3389/fcell.2020.00013 - Fischer T, Hayn A, Mierke CT
Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells
Frontiers in Cell and Developmental Biology 8:393 (2020)
DOI:10.3389/fcell.2020.00393 - Aermes C, Hayn A, Fischer T, Mierke CT
Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices
Scientific Reports 10:13453 (2020)
DOI:10.1038/s41598-020-70428-w
2019
- Kunschmann T, Puder S, Fischer T, Steffen A, Rottner K, Mierke CT
The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices
Scientific Reports 9:7675 (2019)
DOI:10.1038/s41598-019-43975-0 - Fischer T, Hayn A, Mierke CT
Fast and reliable advanced two-step pore-size analysis of biomimetic 3D extracellular matrix scaffolds
Scientific Reports 9:8352 (2019)
DOI:10.1038/s41598-019-44764-5 - Puder S, Fischer T, Mierke CT
The transmembrane protein fibrocystin/polyductin regulates cell mechanics and cell motility
Physical Biology 16:066006 (2019)
DOI:10.1088/1478-3975/ab39fa - Sauer F, Oswald L, Schellenberger AA de, Tzschätzsch H, Schrank F, Fischer T, Braun J, Mierke CT, Valiullin R, Sack I, Käs JA
Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent
Soft Matter 15:3055–3064 (2019)
DOI:10.1039/C8SM02264J - Riedel S, Hietschold P, Krömmelbein C, Kunschmann T, Konieczny R, Knolle W, Mierke CT, Zink M, Mayr SG
Design of biomimetic collagen matrices by reagent-free electron beam induced crosslinking: Structure-property relationships and cellular response
Materials & Design 168:107606 (2019)
DOI:10.1016/j.matdes.2019.107606 - Wilharm N, Fischer T, Ott F, Konieczny R, Zink M, Beck-Sickinger AG, Mayr SG
Energetic electron assisted synthesis of highly tunable temperature-responsive collagen/elastin gels for cyclic actuation: macroscopic switching and molecular origins
Scientific Reports 9:1–7 (2019)
DOI:10.1038/s41598-019-48830-w
2017
- Mierke CT, Fischer T, Puder S, Kunschmann T, Soetje B, Ziegler WH
Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices
Scientific Reports 7:42780 (2017)
DOI:10.1038/srep42780 - Kunschmann T, Puder S, Fischer T, Perez J, Wilharm N, Mierke CT
Integrin-linked kinase regulates cellular mechanics facilitating the motility in 3D extracellular matrices
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:580–593 (2017)
DOI:10.1016/j.bbamcr.2016.12.019 - Fischer T, Wilharm N, Hayn A, Mierke CT
Matrix and cellular mechanical properties are the driving factors for facilitating human cancer cell motility into 3D engineered matrices
Convergent Science Physical Oncology 3:044003–044003 (2017)
DOI:10.1088/2057-1739/aa8bbb
2015
- Sapudom J, Rubner S, Martin S, Fischer T (former Kurth), Riedel S, Mierke CT, Pompe T
The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks
Biomaterials 52:367–375 (2015)
DOI:10.1016/j.biomaterials.2015.02.022
2013
- Mierke CT
The integrin alphav beta3 increases cellular stiffness and cytoskeletal remodeling dynamics to facilitate cancer cell invasion
New Journal of Physics 15:015003 (2013)
DOI:10.1088/1367-2630/15/1/015003 - Mierke CT
Phagocytized Beads Reduce the α5β1 Integrin Facilitated Invasiveness of Cancer Cells by Regulating Cellular Stiffness
Cell Biochemistry and Biophysics 66:599–622 (2013)
DOI:10.1007/s12013-012-9506-3 - Meng D, Francis L, Thompson ID, Mierke CT, Huebner H, Amtmann A, Roy I, Boccaccini AR
Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering
Journal of Materials Science: Materials in Medicine 24:2809–2817 (2013)
DOI:10.1007/s10856-013-5012-4 - Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, Vries U de, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R
LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys
Journal of the American Society of Nephrology 24:1830–1848 (2013)
DOI:10.1681/ASN.2012080788
2012
- Bretz NP, Salnikov AV, Perne C, Keller S, Wang X, Mierke CT, Fogel M, Erbe-Hofmann N, Schlange T, Moldenhauer G, Altevogt P
CD24 controls Src/STAT3 activity in human tumors
Cellular and Molecular Life Sciences 69:3863–3879 (2012)
DOI:10.1007/s00018-012-1055-9
2011
- Mierke CT
Cancer Cells Regulate Biomechanical Properties of Human Microvascular Endothelial Cells
Journal of Biological Chemistry 286:40025–40037 (2011)
DOI:10.1074/jbc.M111.256172 - Jonas O, Mierke CT, Käs JA
Invasive cancer cell lines exhibit biomechanical properties that are distinct from their noninvasive counterparts
Soft Matter 7:11488–11495 (2011)
DOI:10.1039/C1SM05532A - Mierke CT, Bretz N, Altevogt P
Contractile forces contribute to increased GPI-anchored receptor CD24 facilitated cancer cell invasion
Journal of Biological Chemistry jbc.M111.245183 (2011)
DOI:10.1074/jbc.M111.245183 - Mierke CT, Frey B, Fellner M, Herrmann M, Fabry B
Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces
Journal of Cell Science 124:369–383 (2011)
DOI:10.1242/jcs.071985 - Kollmannsberger P, Mierke CT, Fabry B
Nonlinear viscoelasticity of adherent cells is controlled by cytoskeletal tension
Soft Matter 7:3127–3132 (2011)
DOI:10.1039/C0SM00833H
2010
- Marg S, Winkler U, Sestu M, Himmel M, Schönherr M, Bär J, Mann A, Moser M, Mierke CT, Rottner K, Blessing M, Hirrlinger J, Ziegler WH
The Vinculin-ΔIn20/21 Mouse: Characteristics of a Constitutive, Actin-Binding Deficient Splice Variant of Vinculin
PLOS ONE 5:e11530 (2010)
DOI:10.1371/journal.pone.0011530 - Metzner C, Raupach C, Mierke CT, Fabry B
Fluctuations of cytoskeleton-bound microbeads—the effect of bead–receptor binding dynamics
Journal of Physics: Condensed Matter 22:194105 (2010)
DOI:10.1088/0953-8984/22/19/194105 - Mierke CT, Kollmannsberger P, Zitterbart DP, Diez G, Koch TM, Marg S, Ziegler WH, Goldmann WH, Fabry B
Vinculin facilitates cell invasion into 3D collagen matrices
Journal of Biological Chemistry jbc.M109.087171 (2010)
DOI:10.1074/jbc.M109.087171 - Tolde O, Rösel D, Mierke CT, Panková D, Folk P, Vesely P, Brábek J
Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP
International Journal of Oncology 36:833–839 (2010)
DOI:10.3892/ijo_00000560
2009
- Shrestha NK, Macak JM, Schmidt‐Stein F, Hahn R, Mierke CT, Fabry B, Schmuki P
Magnetically Guided Titania Nanotubes for Site-Selective Photocatalysis and Drug Release
Angewandte Chemie International Edition 48:969–972 (2009)
DOI:10.1002/anie.200804429 - Diez G, Kollmannsberger P, Mierke CT, Koch TM, Vali H, Fabry B, Goldmann WH
Anchorage of Vinculin to Lipid Membranes Influences Cell Mechanical Properties
Biophysical Journal 97:3105–3112 (2009)
DOI:10.1016/j.bpj.2009.09.039
2008
- Kalbacova M, Macak JM, Schmidt‐Stein F, Mierke CT, Schmuki P
TiO2 nanotubes: photocatalyst for cancer cell killing
physica status solidi (RRL) – Rapid Research Letters 2:194–196 (2008)
DOI:10.1002/pssr.200802080 - Rösel D, Brábek J, Tolde O, Mierke CT, Zitterbart DP, Raupach C, Bicanová K, Kollmannsberger P, Paňková D, Veselý P, Folk P, Fabry B
Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces
Molecular Cancer Research 6:1410–1420 (2008)
DOI:10.1158/1541-7786.MCR-07-2174 - Mierke CT, Zitterbart DP, Kollmannsberger P, Raupach C, Schlötzer-Schrehardt U, Goecke TW, Behrens J, Fabry B
Breakdown of the Endothelial Barrier Function in Tumor Cell Transmigration
Biophysical Journal 94:2832–2846 (2008)
DOI:10.1529/biophysj.107.113613 - Runz S, Mierke CT, Joumaa S, Behrens J, Fabry B, Altevogt P
CD24 induces localization of β1 integrin to lipid raft domains
Biochemical and Biophysical Research Communications 365:35–41 (2008)
DOI:10.1016/j.bbrc.2007.10.139 - Mierke CT, Kollmannsberger P, Paranhos Zitterbart D, Smith J, Fabry B, Goldmann WH
Mechano-Coupling and Regulation of Contractility by the Vinculin Tail Domain
Biophysical Journal 94:661–670 (2008)
DOI:10.1529/biophysj.107.108472
2007
- Raupach C, Zitterbart DP, Mierke CT, Metzner C, Müller FA, Fabry B
Stress fluctuations and motion of cytoskeletal-bound markers
Physical Review E 76:011918 (2007)
DOI:10.1103/PhysRevE.76.011918 - Bauer K, Mierke CT, Behrens J
Expression profiling reveals genes associated with transendothelial migration of tumor cells: A functional role for αvβ3 integrin
International Journal of Cancer 121:1910–1918 (2007)
DOI:10.1002/ijc.22879
2005
- Sellge G, Laffer S, Mierke CT, Vrtala S, Hoffmann MW, Klempnauer J, Manns MP, Valenta R, Bischoff SC
Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcɛ receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergic reactions
Clinical & Experimental Allergy 35:774–781 (2005)
DOI:10.1111/j.1365-2222.2005.02248.x
2000
- Mierke CT, Ballmaier M, Werner U, Manns MP, Welte K, Bischoff SC
Human Endothelial Cells Regulate Survival and Proliferation of Human Mast Cells
Journal of Experimental Medicine 192:801–812 (2000)
DOI:10.1084/jem.192.6.801
1999
- Lorentz A, Schwengberg S, Mierke CT, Manns MP, Bischoff SC
Human intestinal mast cells produce IL-5 in vitro upon IgE receptor cross-linking and in vivo in the course of intestinal inflammatory disease
European Journal of Immunology 29:1496–1503 (1999)
DOI:10.1002/(SICI)1521-4141(199905)29:05<1496::AID-IMMU1496>3.0.CO;2-5
1998
- Gross T, Richert K, Mierke CT, Lützelberger M, Käufer NF
Identification and characterization of srp1, a gene of fission yeast encoding a RNA binding domain and a RS domain typical of SR splicing factors
Nucleic Acids Research 26:505–511 (1998)
DOI:10.1093/nar/26.2.505
2023
- Mierke CT
Physical and biological advances in endothelial cell-based engineered co-culture model systems
Seminars in Cell and Developmental Biology (2023)
DOI:10.1016/j.semcdb.2023.01.012
2022
- Martinez-Garcia FD, Fischer T, Hayn A, Mierke CT, Burgess JK, Harmsen MC
A Beginner’s Guide to the Characterization of Hydrogel Microarchitecture for Cellular Applications
Gels 8(9):535 (2022)
DOI:10.3390/gels8090535 - Mierke CT
Viscoelasticity, like forces, plays a role in mechanotransduction
Frontiers in Cell and Developmental Biology (2022)
DOI:10.3389/fcell.2022.789841 - Mierke CT
Editorial: Editor’s Pick 2021: Highlights in Cell Adhesion and Migration
Frontiers in Cell and Developmental Biology (2022)
DOI:10.3389/fcell.2022.852781
2021
- Mierke CT
Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics
Frontiers in Cell and Developmental Biology (2021)
DOI:10.3389/fcell.2021.785138 - Mierke CT
Bidirectional Mechanical Response Between Cells and Their Microenvironment
Frontiers in Physics (2021)
DOI:10.3389/fphy.2021.749830 - Mierke CT
The pertinent role of cell and matrix mechanics in cell adhesion and migration
Frontiers in Cell and Developmental Biology (2021)
DOI:10.3389/fcell.2021.720494
2020
- Mierke CT
Cell Mechanics Drives Migration Modes
Biophysical Reviews and Letters 15:1–34 (2020)
DOI:10.1142/S1793048020300017 - Mierke CT
Editorial: Biomechanical Properties of Cells and Tissues and Their Impact on Cellular Adhesion and Motility
Frontiers in Cell and Developmental Biology 8:475 (2020)
DOI:10.3389/fcell.2020.00475 - Mierke CT
Mechanical Cues Affect Migration and Invasion of Cells From Three Different Directions
Frontiers in Cell and Developmental Biology 8:583226 (2020)
DOI:10.3389/fcell.2020.583226
2019
- Mierke CT
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
Reports on Progress in Physics 82:064602 (2019)
DOI:10.1088/1361-6633/ab1628 - Mierke CT
The Role of the Optical Stretcher Is Crucial in the Investigation of Cell Mechanics Regulating Cell Adhesion and Motility
Frontiers in Cell and Developmental Biology 7:184 (2019)
DOI:10.3389/fcell.2019.00184
2018
- Mierke CT, Sauer F, Grosser S, Puder S, Fischer T, Käs JA
The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle
NMR in biomedicine 31:e3831 (2018)
DOI:10.1002/nbm.3831
2017
- Mierke CT
Physical role of nuclear and cytoskeletal confinements in cell migration mode selection and switching
AIMS Biophysics 4:615 (2017)
DOI:10.3934/biophy.2017.4.615
2015
- Mierke CT
Physical View on the Interactions Between Cancer Cells and the Endothelial Cell Lining During Cancer Cell Transmigration and Invasion
Biophysical Reviews and Letters 10:1–24 (2015)
DOI:10.1142/S1793048015300017 - Mierke CT
Physical view on migration modes
Cell Adhesion & Migration 9:367–379 (2015)
DOI:10.1080/19336918.2015.1066958
2014
- Mierke CT
The fundamental role of mechanical properties in the progression of cancer disease and inflammation
Reports on Progress in Physics 77:076602 (2014)
DOI:10.1088/0034-4885/77/7/076602
2013
- Mierke CT
Physical break-down of the classical view on cancer cell invasion and metastasis
European Journal of Cell Biology 92:89–104 (2013)
DOI:10.1016/j.ejcb.2012.12.002 - Mierke CT
The role of focal adhesion kinase in the regulation of cellular mechanical properties
Physical Biology 10:065005 (2013)
DOI:10.1088/1478-3975/10/6/065005
2012
- Mierke CT
Endothelial cell’s biomechanical properties are regulated by invasive cancer cells
Molecular BioSystems 8:1639–1649 (2012)
DOI:10.1039/C2MB25024A
2011
- Mierke CT
The Biomechanical Properties of 3d Extracellular Matrices and Embedded Cells Regulate the Invasiveness of Cancer Cells
Cell Biochemistry and Biophysics 61:217–236 (2011)
DOI:10.1007/s12013-011-9193-5
2010
- Brábek J, Mierke CT, Rösel D, Veselý P, Fabry B
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
Cell Communication and Signaling 8:22 (2010)
DOI:10.1186/1478-811X-8-22 - Kruse K, Janko C, Urbonaviciute V, Mierke CT, Winkler TH, Voll RE, Schett G, Muñoz LE, Herrmann M
Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
Apoptosis 15:1098–1113 (2010)
DOI:10.1007/s10495-010-0478-8
2009
- Mierke CT
The Role of Vinculin in the Regulation of the Mechanical Properties of Cells
Cell Communication and Signaling 53:115–126 (2009)
DOI:10.1007/s12013-009-9047-6
2008
- Mierke CT
Role of the Endothelium during Tumor Cell Metastasis: Is the Endothelium a Barrier or a Promoter for Cell Invasion and Metastasis?
Journal of Biophysics 2008:1–13 (2008)
DOI:10.1155/2008/183516 - Mierke CT, Rösel D, Fabry B, Brábek J
Contractile forces in tumor cell migration
European Journal of Cell Biology 87:669–676 (2008)
DOI:10.1016/j.ejcb.2008.01.002
2007
- Sarter K, Mierke CT, Beer A, Frey B, Führnrohr BG, Schulze C, Franz S
Sweet clearance: Involvement of cell surface glycans in the recognition of apoptotic cells
Autoimmunity 40:345–348 (2007)
DOI:10.1080/08916930701356804
2021
- Claudia Tanja Mierke
Physics of Cancer, Volume 3
Experimental biophysical techniques in cancer research
ISBNs: Hardback: 978-0-7503-3113-5, Mobi: 978-0-7503-3114-2, ePub: 978-0-7503-3115-9, myPrint: 978-0-7503-3116-6
2020
- Claudia Tanja Mierke
Cellular Mechanics and Biophysics
Structure and Function of Basic Cellular Components Regulating Cell Mechanics
eBook ISBN: 978-3-030-58532-7
2018
- Claudia Tanja Mierke
Physics of Cancer, Volume 1 (Second Edition)
Interplay between tumor biology, inflammation and cell mechanics
eBook ISBN: 978-0-7503-1753-5 - Claudia Tanja Mierke
Physics of Cancer, Volume 2 (Second Edition)
Cellular and microenvironmental effects
eBook ISBN: 978-0-7503-2117-4
2015
- Claudia Tanja Mierke
Physics of Cancer
eBook ISBN: 978-0-7503-1134-2
2022
- Biomaterial Based Approaches to Study the Tumor Microenvironment
Biomaterials Science Series
Chapter 4: Mimicking Mechanical Features of the Tumor Microenvironment
2022, Edited By: Jessica O Winter, Shreyas Rao, Royal Society of Chemistry, 486 Pages
ISBN: 978-1-83916-284-8 - Editor’s Pick 2021: Highlights in Cell Adhesion and Migration
2022, PDF and EPUB eBooks available here
ISBN: 978-2-88974-782-5
2020
- The Physics of Cancer
Research Advances
Chapter 5: Cell Mechanics Drives Migration Modes by Claudia Tanja Mierke
2020, Edited By: Bernard S Gerstman (Florida International University, USA), World Scientific, 300 Pages
ISBN: 978-981-122-348-8
2016
- Research on the Physics of Cancer
A Global Perspective
Chapter 2: Physical View on the Interactions Between Cancer Cells and the Endothelial Cell Lining During Cancer Cell Transmigration and Invasion by Claudia Tanja Mierke
2016, Page 19-42, Edited by: Bernard S Gerstman (Florida International University, USA), World Scientific, 220 Pages
ISBN: 978-981-4730-25-9
2015
- Mechanobiology of the Endothelium
Chapter: Cancer Metastasis and Biomechanics of the Endothelium by Claudia Tanja Mierke
2015, Editor Helim Aranda-Espinozsa, CRC Press, 280 Pages
ISBN: 9781482207248
